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KMID : 0367420040470070735
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Journal of Korean Pediatric Society
2004 Volume.47 No. 7 p.735 ~ p.739
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Association between the Human Surfactant Protein-A(SP-A) Gene Locus and Respiratory Distress Syndrome in Korean Neonates.
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Choe Jae-Hoon
Oh Myung-Ho
Ko Jung-Ho
Kim Sun-Young
Lee In-Kyu
Bae Chong-Woo
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Abstract
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Purpose : Respiratory distress syndrome(RDS) is caused by a deficiency of pulmonary surfactant, which is a lipoprotein complex. Both low levels of surfactant protein A(SP-A) and SP-A alleles have been associated with RDS. However, the genes underlying susceptibility to RDS are insufficiently known. The candidate-gene approach was used to study the association between the SP-A gene locus and RDS in the genetically homogeneous Korean population.
Methods : A PCR-cRFLP-based methodology was used to detect SP-A genotype. Twenty four neonates with RDS were matched pairwise to those without RDS.
Results : The frequencies of specific genotypes such as 6A2, 1A0 were increased, but the frequency of specific 1A2 genotype was increased in control group. 6A2/1A0 were also increased in the RDS group. Infants who did not have RDS develop, despite prematurity and lack of steroid therapy, had a higher frequency of the 1A2 allele than infants who had received steroid therapy and had RDS develop. However, infants who had received steroid therapy and had RDS develop had a higher frequency of the 1A0 allele than infants who did not have RDS develop, despite prematurity and lack of steroid therapy.
Conclusion : SP-A alleles/haplotypes are susceptible(6A2, 1A0 , 6A2 /1A0) or protective(1A2 ) factors for RDS. We conclude that the SP-A gene locus is an important determinant for predisposition to RDS in neonates. (Korean J Pediatr 2004;47:735-739)
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KEYWORD
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Surfactant, Pulmonary surfactant associated protein-A, Respiratory distress syndrome, Steroids
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